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Covid-19 (thesaurus)

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Concept information

... > virus > viral tropism > host cell > host cell protein > host cell protease > kinase > Janus kinase > Janus kinase 1
... > virus-host interaction > protein marker > host cell protein > host cell protease > kinase > Janus kinase > Janus kinase 1
clinical research > candidate treatment > therapeutic target > Janus kinase > Janus kinase 1

Preferred term

Janus kinase 1  

Definition

  • JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. (Wikipedia)

Broader concept

Entry terms

  • JAK1

Creator

  • Patricia Fener

In other languages

URI

http://data.loterre.fr/ark:/67375/C0X-VBHG595P-9

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