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Concept information

virus > variant virus > new coronavirus variant > VUI-202012/01

Terme préférentiel

VUI-202012/01  

Définition

  • Variant of Concern 202012/01 (VOC-202012/01; also known as lineage B.1.1.7, see § Nomenclature) is a variant of SARS-CoV-2, the virus that causes COVID-19. The variant was first detected in October 2020 during the COVID-19 pandemic in the United Kingdom from a sample taken the previous month, and it quickly began to spread by mid-December. It is correlated with a significant increase in the rate of COVID-19 infection in United Kingdom; this increase is thought to be at least partly because of change N501Y (see nomenclature for mutations) inside the spike glycoprotein's receptor-binding domain, which is needed for binding to ACE2 in human cells. The variant is also notable for the higher number of mutations it contains compared to the recorded trend to date. (Wikipédia)

Concept générique

Concepts associés

Synonyme(s)

  • Variant Of Concern-202012/01
  • Variant of Concern, year 2020, month 12, variant 01
  • "Variant Under Investigation” in December 2020
  • VOC-202012/01

Note

  • On 14 December 2020, authorities of the United Kingdom reported to WHO a variant referred to by the United Kingdom as SARS-CoV-2 VOC 202012/01 (Variant of Concern, year 2020, month 12, variant 01). This variant contains 23 nucleotide substitutions and is not phylogenetically related to the SARS-CoV-2 virus circulating in the United Kingdom at the time the variant was detected. How and where SARS-CoV-2 VOC 202012/01 originated is unclear. SARS-CoV-2 VOC 202012/01 initially appeared in South East England but within a few weeks began to replace other virus lineages in this geographic area and London. As of 26 December 2020, SARS-CoV-2 VOC 202012/01 has been identified from routine sampling and genomic testing conducted across the United Kingdom . Preliminary epidemiologic, modelling, phylogenetic and clinical findings suggest that SARS-CoV-2 VOC 202012/01 has increased transmissibility. WHO. « SARS-CoV-2 Variants ». (Retrieved 08/12/2020, from https://www.who.int/ )
  • The new SARS-CoV-2 variant has been snappily named VUI-202012/01 (the first “Variant Under Investigation” in December 2020) and is defined by a set of 17 changes or mutations. One of the most significant is an N501Y mutation in the spike protein that the virus uses to bind to the human ACE2 receptor. Changes in this part of spike protein may, in theory, result in the virus becoming more infectious and spreading more easily between people. Gov.UK. "Second COVID-19 vaccine authorised by medicines regulator." (Retrieved 08/12/2020, from https://www.gov.uk. )

Créateur

  • Patricia Fener

Traductions

  • VUI-202012/01

    français

  • variant Under Investigation, année 2020, mois 12, variant 01
  • VOC-202012/01

URI

http://data.loterre.fr/ark:/67375/C0X-R7GK2HSS-7

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RDF/XML TURTLE JSON-LD Date de création 03/01/2021, dernière modification le 05/01/2021