Concept information
Preferred term
AlkB Enzymes
Type
-
mesh:Descriptor
Definition
- A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Broader concept
Narrower concepts
- AlkB Homolog 1, Histone H2a Dioxygenase
- AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 4, Lysine Demethylase
- AlkB Homolog 5, RNA Demethylase
- AlkB Homolog 8, tRNA Methyltransferase
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Entry terms
- AlkB Homologs
- Alkylated DNA Repair Protein AlkB Homologs
- Alkylation Repair Homolog Proteins
- Alkylation Repair Homologs
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
Enzymes AlkB
-
Homologues de AlkB
-
Homologues de la protéine AlkB de réparation de l'ADN alkylé
-
Homologues de la protéine de réparation de l'alkylation
URI
http://data.loterre.fr/ark:/67375/JVR-B5GWZC5Q-Q
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