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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 17-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 17-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Steroid Hydroxylases > Steroid 17-alpha-Hydroxylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Mixed Function Oxygenases > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 17 > Steroid 17-alpha-Hydroxylase
... > Amino Acids, Peptides, and Proteins > Proteins > Hemeproteins > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 17 > Steroid 17-alpha-Hydroxylase
Enzymes and Coenzymes > Cytochromes > Cytochrome P-450 Enzyme System > Cytochrome P450 Family 17 > Steroid 17-alpha-Hydroxylase

Preferred term

Steroid 17-alpha-Hydroxylase  

Type

  • mesh:Descriptor

Definition

  • A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Broader concept

Related concepts

Entry terms

  • 17,20-Desmolase
  • 17,20-Lyase
  • 17 alpha-Hydroxylase
  • 17 alpha-Hydroxylase Cytochrome P-450
  • 62213-24-5 (CAS RN)
  • 9029-67-8 (CAS RN)
  • CYP17
  • Cytochrome P-450(17 alpha)
  • Cytochrome P-450(17-alpha)
  • Cytochrome P450(17 alpha)
  • P450(c17)
  • Steroid 17 alpha-Hydroxylase
  • Steroid 17 alpha-Monooxygenase
  • Steroid 17-Hydroxylase
  • Steroid-17-Hydroxylase
  • Steroid 17-Monooxygenase
  • Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)

Allowable Qualifier(s)

In other languages

  • Steroid 17-alpha-hydroxylase

    French

  • 17-alpha-Hydroxylase
  • 62213-24-5 (CAS RN)
  • 9029-67-8 (CAS RN)
  • CYP 17
  • CYP17
  • Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
  • Stéroïde 17-alpha-hydroxylase
  • Stéroïde 17-alpha-monooxygénase

URI

http://data.loterre.fr/ark:/67375/JVR-B6DD9TM0-G

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