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... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Purine Nucleosides > Adenosine > Deoxyadenosines > Dideoxyadenosine
... > Carbohydrates > Glycosides > Nucleosides > Purine Nucleosides > Adenosine > Deoxyadenosines > Dideoxyadenosine
... > Heterocyclic Compounds > Heterocyclic Compounds, Fused-Ring > Heterocyclic Compounds, 2-Ring > Purines > Purine Nucleosides > Adenosine > Deoxyadenosines > Dideoxyadenosine
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Ribonucleosides > Adenosine > Deoxyadenosines > Dideoxyadenosine
... > Carbohydrates > Glycosides > Nucleosides > Ribonucleosides > Adenosine > Deoxyadenosines > Dideoxyadenosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Deoxyadenosines > Dideoxyadenosine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Deoxyadenosines > Dideoxyadenosine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Dideoxyadenosine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Dideoxyadenosine

Preferred term

Dideoxyadenosine  

Type

  • mesh:Descriptor

Definition

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.

Broader concept

Entry terms

  • 2',3'-Dideoxyadenosine
  • 4097-22-7 (Dideoxyadenosine)
  • 4Q86AH641A
  • Adenosine, 2',3'-dideoxy-
  • ddA (Antiviral)

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Didéoxyadénosine

    French

  • 4097-22-7 (Dideoxyadenosine)
  • 4Q86AH641A
  • Adenosine, 2',3'-dideoxy-

URI

http://data.loterre.fr/ark:/67375/JVR-BH1R6L2Q-F

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RDF/XML TURTLE JSON-LD Created 7/14/89, last modified 5/31/16