Concept information
Preferred term
Steroid 12-alpha-Hydroxylase
Type
-
mesh:Descriptor
Definition
- A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Broader concept
Entry terms
- 12-alpha-Hydroxylase
- 12alpha-Hydroxylase
- CYP8B1
- Cytochrome P450 8B1
- Cytochrome P450 CYP8B1
- Steroid 12-Hydroxylase
- Steroid-12-Hydroxylase
- Steroid 12-Monooxygenase
- Steroid-12-Monooxygenase
- Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
- Sterol 12 alpha-Hydroxylase
- Sterol 12-alpha-Hydroxylase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
12-alpha-hydroxylase
-
CYP 8B1
-
CYP8B1
-
Cytochrome P450 8B1
-
Cytochrome P450 CYP8B1
-
Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
-
Stéroïde 12-alpha-hydroxylase
-
Stéroïde 12-alpha-monooxygénase
-
Stérol 12-alpha-hydroxylase
URI
http://data.loterre.fr/ark:/67375/JVR-BNT0MBJW-8
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