Concept information
Preferred term
Methotrexate
Type
-
mesh:Descriptor
Definition
- An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Broader concept
Entry terms
- 133073-73-1 (x.H2O)
- 15475-56-6 (Na salt)
- 3IG1E710ZN
- 51865-79-3 ((D)-isomer)
- 59-05-2 (Methotrexate)
- 60388-53-6 ((DL)-isomer)
- 86669-44-5 (di-Cs salt)
- Amethopterin
- L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
- YL5FZ2Y5U1
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
133073-73-1 (x.H2O)
-
15475-56-6 (Na salt)
-
3IG1E710ZN
-
51865-79-3 ((D)-isomer)
-
59-05-2 (Methotrexate)
-
60388-53-6 ((DL)-isomer)
-
86669-44-5 (di-Cs salt)
-
Améthoptérine
-
L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
-
Méthylaminoptérine
-
YL5FZ2Y5U1
URI
http://data.loterre.fr/ark:/67375/JVR-C27LRJKB-8
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