Concept information
Preferred term
Tissue Plasminogen Activator
Type
-
mesh:Descriptor
Definition
- A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Broader concept
Narrower concepts
Entry terms
- 105857-23-6 (Alteplase)
- Alteplase
- Plasminogen Activator, Tissue-Type
- Tisokinase
- Tissue Activator D-44
- Tissue-Type Plasminogen Activator
- T-Plasminogen Activator
- TTPA
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
105857-23-6 (Alteplase)
-
Altéplase
-
t-PA (t-Plasminogen Activator)
-
tPA (tissue Plasminogen Activator)
URI
http://data.loterre.fr/ark:/67375/JVR-C8BHCSFT-7
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