: MeSH: RNA, Small Interfering

... > Nucleic Acids > RNA > RNA, Untranslated > RNA, Small Untranslated > RNA, Small Interfering

Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > RNA > RNA, Antisense > RNA, Small Interfering

... > Molecular Probes > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering

... > Nucleic Acids > Nucleic Acid Probes > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering

RNA, Small Interfering

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions. siRNAs, about 26-31 nucleotides in length. They are involved in mammalian GAMETOGENESIS. siRNAs involved with GENE SILENCING of MOBILE GENETIC ELEMENTS in DROSOPHILA. siRNAs, found in TETRAHYMENA, that are homologous to internal eliminated sequences (IESs) deleted during programmed genome rearrangement. siRNA, found in plants, that are involved in silencing different gene loci than those from which they were derived.

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