Concept information
Preferred term
Insulin-Like Growth Factor Binding Protein 1
Type
-
mesh:Descriptor
Definition
- One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
Broader concept
Entry terms
- IGF-Binding Protein 1
- IGFBP-1
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
IGFBP-1
-
Protéine de liaison au facteur de croissance insulinoïde de type 1
-
Protéine de liaison au facteur de croissance insulinomimétique de type 1
-
Protéine de liaison au FCI-1
-
Protéine de liaison de l'IGF de type 1
-
Protéine IGFBP-1
-
Protéine liant l'IGF-1
-
Protéine-1 de liaison au facteur de croissance insuline-like
-
Protéine-1 de liaison au facteur de croissance insulinomimétique
-
Protéine-1 de liaison du facteur de croissance insuline-like
-
Protéine-1 se liant aux IGF
URI
http://data.loterre.fr/ark:/67375/JVR-DJBBW2X1-H
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