: MeSH: Genes, Wilms Tumor

... > Genome Components > Genes > Genes, Neoplasm > Genes, Tumor Suppressor > Genes, Wilms Tumor

Genetic Phenomena > Inheritance Patterns > Genes, Recessive > Genes, Tumor Suppressor > Genes, Wilms Tumor

... > Genome Components > Genes > Genes, Recessive > Genes, Tumor Suppressor > Genes, Wilms Tumor

Genes, Wilms Tumor

Genes at loci that are involved in the development of WILMS TUMOR. Included are human WT1 at 11p13 and human WT2 (MTACR1) at 11p15. Genes located at on the short arm of chromosome 11, at band p15 whose absence is associated with the formation of Wilms tumor. This Wilms tumor locus is also associated with BECKWITH-WIEDEMANN SYNDROME. Tumor suppressor gene located in the 11p13 region on the short arm of human chromosome 11. The absence of this gene is associated with the formation of Wilms tumor. It encodes several isoforms that are zinc finger containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.

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