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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Protein Domains > Discoidin Domain
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Tertiary > Protein Domains > Discoidin Domain

Preferred term

Discoidin Domain  

Type

  • mesh:Descriptor

Definition

  • A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a "jellyroll" configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.

Broader concept

Entry terms

  • Discoidin Domains

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-DKF52SD9-T

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/9/16