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... > Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin > Insulin
... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones > Pancreatic Hormones > Insulins > Proinsulin > Insulin
Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Proinsulin > Insulin

Preferred term

Insulin  

Type

  • mesh:Descriptor

Definition

  • A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Broader concept

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Related concepts

Entry terms

  • Insulin, Regular
  • Soluble Insulin

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Insuline

    French

  • Insuline ordinaire
  • Insuline soluble

URI

http://data.loterre.fr/ark:/67375/JVR-DPP5ZDP3-H

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