Concept information
Preferred term
Cisplatin
Type
-
mesh:Descriptor
Definition
- An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Broader concept
Entry terms
- 15663-27-1 (Cisplatin)
- cis-Diamminedichloroplatinum
- cis-Diamminedichloroplatinum(II)
- cis-Dichlorodiammineplatinum(II)
- cis-Platinum
- Dichlorodiammineplatinum
- Platinum, diamminedichloro-, (SP-4-2)-
- Platinum Diamminodichloride
- Q20Q21Q62J
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
15663-27-1 (Cisplatin)
-
cis-Diamminedichloroplatine(II)
-
cis-Platine
-
Platinum, diamminedichloro-, (SP-4-2)-
-
Q20Q21Q62J
URI
http://data.loterre.fr/ark:/67375/JVR-DPTS7TDV-D
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