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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1 > Complement C1s
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C1s
Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C1s

Preferred term

Complement C1s  

Type

  • mesh:Descriptor

Definition

  • A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).

Broader concept

Entry terms

  • C 1 Esterase
  • C1 Esterase
  • C1s Complement
  • Complement 1 Esterase
  • Complement 1s
  • Complement Component 1s

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Complément C1s

    French

  • C1 estérase
  • Complément 1s
  • Complement C1 Esterase
  • Composant C1s du complément
  • Fraction C1s du complément
  • Fragment C1s du complément

URI

http://data.loterre.fr/ark:/67375/JVR-DV3XXGG0-W

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RDF/XML TURTLE JSON-LD Created 5/16/77, last modified 7/5/06