: MeSH: Atrial Natriuretic Factor

Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Natriuretic Peptides > Atrial Natriuretic Factor

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Atrial Natriuretic Factor

A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. An antiparallel dimer of alpha-ANP with the chains linked by 7-23' and 7'-23 disulfide bonds. A potent circulating form of ANP that is a 28-amino acid peptide. It derives from the (99-126) amino acids of prohormone gamma-ANP, also known as ANP (1-126). Polypeptides of about 150 amino acids that serve as precursors to prohormone of ATRIAL NATRIURETIC FACTOR, a 126-amino acid polypeptide or ANP (1-126). The 126-amino acid C-terminal fragment of the ANP precursor, an approximately 150-amino acid polypeptide in a number of species. It is formed by the removal of the N-terminal signal sequence ANP (1-24). This prohormone contains various active ANF sequences.

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