: MeSH: Tumor Suppressor p53-Binding Protein 1

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Tumor Suppressor p53-Binding Protein 1

Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Tumor Suppressor p53-Binding Protein 1

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Tumor Suppressor p53-Binding Protein 1

Tumor Suppressor p53-Binding Protein 1

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

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