Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Protein Domains > Pleckstrin Homology Domains
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Tertiary > Protein Domains > Pleckstrin Homology Domains

Preferred term

Pleckstrin Homology Domains  

Type

  • mesh:Descriptor

Definition

  • Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.

Broader concept

Related concepts

Entry terms

  • PH Domain
  • PH Domains
  • Pleckstrin Homology Domain

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-F9PGJ9SZ-S

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/9/16