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Circulatory and Respiratory Physiological Phenomena > Blood Physiological Phenomena > Hematopoiesis > Clonal Hematopoiesis
Cell Physiological Phenomena > Cell Differentiation > Hematopoiesis > Clonal Hematopoiesis
Cell Physiological Phenomena > Clonal Evolution > Clonal Hematopoiesis
Genetic Phenomena > Clonal Evolution > Clonal Hematopoiesis

Preferred term

Clonal Hematopoiesis  

Type

  • mesh:Descriptor

Definition

  • Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).

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URI

http://data.loterre.fr/ark:/67375/JVR-FNVPFQ7G-3

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RDF/XML TURTLE JSON-LD Created 7/7/20, last modified 5/27/20