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... > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Protease Inhibitors > Serine Proteinase Inhibitors > Serine Peptidase Inhibitors, Kazal Type > Serine Peptidase Inhibitor Kazal-Type 5
Amino Acids, Peptides, and Proteins > Peptides > Proteinase Inhibitory Proteins, Secretory > Serine Peptidase Inhibitors, Kazal Type > Serine Peptidase Inhibitor Kazal-Type 5
Amino Acids, Peptides, and Proteins > Proteins > Proteinase Inhibitory Proteins, Secretory > Serine Peptidase Inhibitors, Kazal Type > Serine Peptidase Inhibitor Kazal-Type 5

Preferred term

Serine Peptidase Inhibitor Kazal-Type 5  

Type

  • mesh:Descriptor

Definition

  • A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.

Broader concept

Related concepts

Entry terms

  • LEKTI Protein
  • Lympho-Epithelial Kazal-Type Inhibitor
  • Serine Protease Inhibitor Kazal-Type 5
  • SPINK5 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-FS6T4VXW-K

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 2/24/17