Concept information
Preferred term
Angiotensin-Converting Enzyme 2
Type
-
mesh:Descriptor
Definition
- A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
Broader concept
Entry terms
- ACE2 Angiotensin-Converting Enzyme Protein 2
- ACE2 Enzyme
- ACE2 Protein
- ACE-Related Carboxypeptidase
- Angiotensin Converting Enzyme 2
- Angiotensin-Converting Enzyme-Related Carboxypeptidase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
Carboxypeptidase de type ACE
-
Carboxypeptidase de type enzyme de conversion de l'angiotensine
-
Enzyme ACE2
-
Enzyme-2 de conversion de l'angiotensine
-
Protéine ACE2
URI
http://data.loterre.fr/ark:/67375/JVR-G0DDWFVX-W
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