Concept information
Preferred term
DNA-(Apurinic or Apyrimidinic Site) Lyase
Type
-
mesh:Descriptor
Definition
- A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Broader concept
Entry terms
- AP Endonuclease
- AP Lyase
- Apurine-Apyrimidine Endonuclease
- Apurinic DNA Endonuclease
- Apurinic Endonuclease
- DNA Lyase (Apurinic or Apyrimidinic)
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
ADN apurinique endonucléase
-
ADN lyase (site apurinique ou apyrimidique)
-
Endodésoxyribonucléase (site apurinique ou apyrimi dique)
URI
http://data.loterre.fr/ark:/67375/JVR-G1876FXS-S
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