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Macromolecular Substances > Multiprotein Complexes > Shelterin Complex
... > Genetic Phenomena > Genetic Structures > Chromosomes > Chromosome Structures > Telomere > Shelterin Complex
... > Cells > Cellular Structures > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Organelles > Cell Nucleus > Cell Nucleus Structures > Intranuclear Space > Chromosomes > Chromosome Structures > Telomere > Shelterin Complex
... > Fluids and Secretions > Body Fluids > Body Fluid Compartments > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Organelles > Cell Nucleus > Cell Nucleus Structures > Intranuclear Space > Chromosomes > Chromosome Structures > Telomere > Shelterin Complex
... > Tissues > Body Fluid Compartments > Intracellular Space > Cytoplasm > Cytoplasmic Structures > Organelles > Cell Nucleus > Cell Nucleus Structures > Intranuclear Space > Chromosomes > Chromosome Structures > Telomere > Shelterin Complex
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Telomere-Binding Proteins > Shelterin Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Telomere-Binding Proteins > Shelterin Complex
... > Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Telomere-Binding Proteins > Shelterin Complex

Preferred term

Shelterin Complex  

Type

  • mesh:Descriptor

Definition

  • A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

Broader concept

Narrower concepts

Entry terms

  • POT1-TPP1 Shelterin Complex
  • Telomere POT1-TPP1 Complex
  • Telosome

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-GJKN3KTK-5

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RDF/XML TURTLE JSON-LD Created 7/9/21, last modified 6/30/21