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... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > Genes > Genes, Neoplasm > Genes, Tumor Suppressor > Genes, BRCA2
Genetic Phenomena > Inheritance Patterns > Genes, Recessive > Genes, Tumor Suppressor > Genes, BRCA2
... > Genetic Phenomena > Genetic Structures > Genome > Genome Components > Genes > Genes, Recessive > Genes, Tumor Suppressor > Genes, BRCA2

Preferred term

Genes, BRCA2  

Type

  • mesh:Descriptor

Definition

  • A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

Broader concept

Related concepts

Entry terms

  • BRCA2 Gene

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-GXSXX0C7-K

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RDF/XML TURTLE JSON-LD Created 7/25/01, last modified 7/8/08