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Immune System Diseases > Autoimmune Diseases > Autoimmune Diseases of the Nervous System > Demyelinating Autoimmune Diseases, CNS > Encephalomyelitis, Autoimmune, Experimental
Nervous System Diseases > Autoimmune Diseases of the Nervous System > Demyelinating Autoimmune Diseases, CNS > Encephalomyelitis, Autoimmune, Experimental
Nervous System Diseases > Demyelinating Diseases > Demyelinating Autoimmune Diseases, CNS > Encephalomyelitis, Autoimmune, Experimental
... > Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Leukoencephalopathies > Demyelinating Autoimmune Diseases, CNS > Encephalomyelitis, Autoimmune, Experimental
Immune System Diseases > Autoimmune Diseases > Autoimmune Diseases of the Nervous System > Nervous System Autoimmune Disease, Experimental > Encephalomyelitis, Autoimmune, Experimental
Nervous System Diseases > Autoimmune Diseases of the Nervous System > Nervous System Autoimmune Disease, Experimental > Encephalomyelitis, Autoimmune, Experimental
Animal Diseases > Disease Models, Animal > Nervous System Autoimmune Disease, Experimental > Encephalomyelitis, Autoimmune, Experimental
... > Investigative Techniques > Models, Theoretical > Models, Biological > Disease Models, Animal > Nervous System Autoimmune Disease, Experimental > Encephalomyelitis, Autoimmune, Experimental
Investigative Techniques > Models, Animal > Disease Models, Animal > Nervous System Autoimmune Disease, Experimental > Encephalomyelitis, Autoimmune, Experimental

Preferred term

Encephalomyelitis, Autoimmune, Experimental  

Type

  • mesh:Descriptor

Definition

  • An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)

Broader concept

Entry terms

  • Allergic Encephalomyelitis
  • Allergic Encephalomyelitis, Experimental
  • Autoimmune Encephalomyelitis, Experimental
  • Autoimmune Experimental Encephalomyelitis
  • Encephalomyelitis, Allergic
  • Encephalomyelitis, Experimental Autoimmune
  • Experimental Allergic Encephalomyelitis
  • Experimental Autoimmune Encephalomyelitis

Allowable Qualifier(s)

In other languages

  • Encéphalomyélite auto-immune expérimentale

    French

  • EAE (Encéphalomyélite Auto-immune Expérimentale)
  • Encéphalomyélite allergique
  • Encéphalomyélite allergique expérimentale
  • Encéphalomyélite autoimmune expérimentale

URI

http://data.loterre.fr/ark:/67375/JVR-H2DZ68Z1-B

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