: MeSH: Darier Disease

Skin and Connective Tissue Diseases > Skin Diseases > Keratosis > Darier Disease

Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Skin Diseases, Genetic > Darier Disease

Skin and Connective Tissue Diseases > Skin Diseases > Skin Diseases, Genetic > Darier Disease

Darier Disease

An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES. An alleleic variant of Darier's disease.

http://data.loterre.fr/ark:/67375/JVR-H5Z7J9GX-V

RDF/XML TURTLE JSON-LD Created 1/1/99, last modified 6/18/15

Loterre