: MeSH: Zinc Finger Protein Gli3

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Zinc Finger Protein Gli3

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Zinc Finger Protein Gli3

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Kruppel-Like Transcription Factors > Zinc Finger Protein Gli3

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Kruppel-Like Transcription Factors > Zinc Finger Protein Gli3

Zinc Finger Protein Gli3

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

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