Concept information
Preferred term
Folic Acid Antagonists
Type
-
mesh:Descriptor
Definition
- Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Broader concept
Entry terms
- Antifolate
- Antifolates
- Dihydrofolate Reductase Inhibitor
- Dihydrofolate Reductase Inhibitors
- Folic Acid Antagonist
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
Antagonistes de l'acide folique
-
Anti-folates
-
Anti-foliques
-
Antifolates
URI
http://data.loterre.fr/ark:/67375/JVR-HMPWGQQZ-2
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