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... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > Proto-Oncogene Proteins c-bcl-2 > bcl-X Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > Proto-Oncogene Proteins c-bcl-2 > bcl-X Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > Proto-Oncogene Proteins c-bcl-2 > bcl-X Protein

Preferred term

bcl-X Protein  

Type

  • mesh:Descriptor

Definition

  • A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS and is a regulatory subunit for PROTEIN PHOSPHATASE 1. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL. A pro-apoptotic protein that is the short isoform of Bcl-X protein. Bcl-XS lacks the BH1 and BH2 domains of BCL-XL PROTEIN and it inhibits the ANTI-APOPTOTIC PROTEINS of the bcl-2 protein family. Bcl-XL is an anti-apoptotic protein that is the long isoform of Bcl-X protein. Bcl-XL localizes to the outer mitochondrial membrane and is overexpressed in most human NEOPLASMS. It has also been implicated in ISCHEMIC HEART DISEASE.

Broader concept

Entry terms

  • bcl2L1 Protein
  • bcl2-Like 1 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-HN07X5GT-C

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 12/1/15