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... > Neoplasms > Neoplasms by Histologic Type > Neoplasms, Germ Cell and Embryonal > Trophoblastic Neoplasms > Gestational Trophoblastic Disease > Hydatidiform Mole
... > Urogenital Diseases > Female Urogenital Diseases and Pregnancy Complications > Pregnancy Complications > Pregnancy Complications, Neoplastic > Trophoblastic Neoplasms > Gestational Trophoblastic Disease > Hydatidiform Mole
Neoplasms > Pregnancy Complications, Neoplastic > Trophoblastic Neoplasms > Gestational Trophoblastic Disease > Hydatidiform Mole

Preferred term

Hydatidiform Mole  

Type

  • mesh:Descriptor

Definition

  • Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype. Derived from the fertilization of an anuclear ovum by one or sometimes two haploid sperm. Its molar chromosomes derive entirely from the paternal origin. It has no identifiable embryonic or fetal tissue. The chorionic villi have generalized swelling and diffuse trophoblastic hyperplasia. Most complete moles (>90%) have a 46,XX karyotype and the rest 46,XY karyotype. Derived from the fertilization of an apparently normal ovum by two sperm. Partial hydatidiform moles are characterized by focal chorionic villi swelling, focal trophoblastic hyperplasia, and identifiable fetal or embryonic tissue. Partial moles generally have a triploid karyotype.

Broader concept

Narrower concepts

Entry terms

  • Hydatid Mole
  • Molar Pregnancy
  • Pregnancy, Molar

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URI

http://data.loterre.fr/ark:/67375/JVR-HRMSJMJ5-N

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