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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Inhibition Motif
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Secondary > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Inhibition Motif

Preferred term

Immunoreceptor Tyrosine-Based Inhibition Motif  

Type

  • mesh:Descriptor

Definition

  • A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

Broader concept

Entry terms

  • Immune Receptor Tyrosine-Based Inhibition Motif
  • Immuno-Receptor Tyrosine-Based Inhibition Motif

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-HTRMN606-4

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RDF/XML TURTLE JSON-LD Created 7/3/12, last modified 7/5/16