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... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Oxidoreductases, N-Demethylating > Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > AlkB Enzymes > Alpha-Ketoglutarate-Dependent Dioxygenase FTO
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Dioxygenases > AlkB Enzymes > Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Preferred term

Alpha-Ketoglutarate-Dependent Dioxygenase FTO  

Type

  • mesh:Descriptor

Definition

  • A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

Broader concept

Entry terms

  • AlkB Homolog 9 Protein
  • Alpha-Ketoglutarate-Dependent Dioxygenase
  • Fat Mass and Obesity Associated (FTO) Protein
  • Fat Mass and Obesity Associated Protein

Allowable Qualifier(s)

In other languages

  • Alpha-ketoglutarate-dependent dioxygenase FTO

    French

  • Dioxygénase dépendante de l'alpha-cétoglutarate
  • Dioxygénase dépendante de l'oxoglutarate
  • Dioxygénase FTO dépendante de l'alpha-cétoglutarate
  • Dioxygénase FTO dépendante de l'oxoglutarate
  • Fat mass and obesity associated (FTO) protein
  • Protéine associée à la masse grasse et à l'obésité
  • Protéine-9 homologue de AlkB

URI

http://data.loterre.fr/ark:/67375/JVR-HWTRVP58-P

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 6/28/16