Concept information
Preferred term
Complement Membrane Attack Complex
Type
-
mesh:Descriptor
Definition
- A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Broader concept
Entry terms
- C5b-8-poly-C9
- C 5b-9
- C5b-9
- Complement Complex C5b-9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- Terminal Complement Complex
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
Complexe C5b-9
-
Complexe d'attaque membranaire
-
Complexe lytique terminal du complément
URI
http://data.loterre.fr/ark:/67375/JVR-J2XJX3ZP-7
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