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Concept information

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > NFATC Transcription Factors

Preferred term

NFATC Transcription Factors  

Type

  • mesh:Descriptor

Definition

  • A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. A signal-dependent transcription factor that controls cellular response to osmotic stress. NFAT5 is closely related to NFATC PROTEINS but resides constitutively in the CELL NUCLEUS and operates independently of CALCINEURIN and TRANSCRIPTION FACTOR AP-1.

Broader concept

Entry terms

  • NFATC Proteins
  • NF-AT Proteins
  • NFAT Proteins
  • Nuclear Factor of Activated T-Cells, Cytoplasmic
  • Nuclear Factors of Activated T-Cells
  • Transcription Factor NF-AT

Allowable Qualifier(s)

In other languages

  • Facteurs de transcription NFATC

    French

  • Facteur de transcription NF-AT
  • Facteur transcriptionnel NF-AT
  • Facteurs nucléaires des cellules T activées
  • Facteurs nucléaires des lymphocytes T activés
  • Facteurs transcriptionnels NFATC
  • Protéines NF-AT
  • Protéines NFAT
  • Protéines NFATC

URI

http://data.loterre.fr/ark:/67375/JVR-JHK3X299-6

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 7/9/13