Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Macromolecular Substances > Multiprotein Complexes > Mitochondrial Permeability Transition Pore
Amino Acids, Peptides, and Proteins > Proteins > Mitochondrial Proteins > Mitochondrial Membrane Transport Proteins > Mitochondrial Permeability Transition Pore
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Mitochondrial Membrane Transport Proteins > Mitochondrial Permeability Transition Pore
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Mitochondrial Membrane Transport Proteins > Mitochondrial Permeability Transition Pore

Preferred term

Mitochondrial Permeability Transition Pore  

Type

  • mesh:Descriptor

Definition

  • A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.

Broader concept

Entry terms

  • Mitochondrial Megachannel
  • Mitochondrial Permeability Transition Pore (mPTP)
  • mPTP Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-JNBD52V9-5

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/7/20, last modified 2/21/20