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... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement C1 > Complement C1r
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Activating Enzymes > Complement C1r
Enzymes and Coenzymes > Enzymes > Hydrolases > Complement Activating Enzymes > Complement C1r

Preferred term

Complement C1r  

Type

  • mesh:Descriptor

Definition

  • A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.

Broader concept

Entry terms

  • C1r Complement
  • Complement 1r
  • Complement Component 1r

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Complément C1r

    French

  • Complément 1r
  • Composant C1r du complément
  • Fraction C1r du complément
  • Fragment C1r du complément

URI

http://data.loterre.fr/ark:/67375/JVR-JRNTFZ8M-9

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RDF/XML TURTLE JSON-LD Created 5/25/89, last modified 7/5/06