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Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Autophagy-Related Protein-1 Homolog
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Autophagy-Related Protein-1 Homolog
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Autophagy-Related Protein-1 Homolog
Amino Acids, Peptides, and Proteins > Proteins > Autophagy-Related Proteins > Autophagy-Related Protein-1 Homolog

Preferred term

Autophagy-Related Protein-1 Homolog  

Type

  • mesh:Descriptor

Definition

  • A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.

Broader concept

Entry terms

  • Serine-Threonine Protein Kinase ULK1
  • ULK1 Protein
  • Unc-51 Like Autophagy Activating Kinase 1
  • Unc-51-Like Kinase 1

Allowable Qualifier(s)

In other languages

  • Homologue de la protéine-1 associée à l'autophagie

    French

  • Homologue de la protéine-1 liée à l'autophagie
  • Kinase-1 activant l'autophagie analogue à unc-51
  • Kinase-1 analogue à unc-51
  • Protéine ULK1
  • Serine-threonine protein kinase ULK1
  • Sérine-thréonine protéine kinase ULK1

URI

http://data.loterre.fr/ark:/67375/JVR-JTNRJF78-9

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/28/21