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... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > Multidrug Resistance-Associated Proteins
... > Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > Multidrug Resistance-Associated Proteins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > ATP-Binding Cassette Transporters > Multidrug Resistance-Associated Proteins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > Multidrug Resistance-Associated Proteins
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > ATP-Binding Cassette Transporters > Multidrug Resistance-Associated Proteins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > Multidrug Resistance-Associated Proteins
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Ion Pumps > Anion Transport Proteins > Organic Anion Transporters > Organic Anion Transporters, ATP-Dependent > Multidrug Resistance-Associated Proteins

Preferred term

Multidrug Resistance-Associated Proteins  

Type

  • mesh:Descriptor

Definition

  • A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.

Broader concept

Narrower concepts

Related concepts

Entry terms

  • ATP-Binding Cassette, Sub-Family C Proteins
  • MOAT Protein
  • Multidrug Resistance-Associated Protein
  • Multispecific Organic Anion Transporter
  • Multispecific Organic Anion Transport Proteins

Allowable Qualifier(s)

In other languages

  • Protéines associées à la multirésistance aux médicaments

    French

  • Protéines associées à la résistance médicamenteuse multiple
  • Protéines associées à la résistance multiple aux médicaments
  • Protéines associées à MDR
  • Protéines de la sous-famille C de cassette de liaison à l'ATP
  • Transporteurs multispécifiques d'anions organiques

URI

http://data.loterre.fr/ark:/67375/JVR-JVCPPN5G-K

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RDF/XML TURTLE JSON-LD Created 7/25/01, last modified 7/13/18