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... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 3 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 3 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Suppressor of Cytokine Signaling Proteins > Suppressor of Cytokine Signaling 3 Protein

Preferred term

Suppressor of Cytokine Signaling 3 Protein  

Type

  • mesh:Descriptor

Definition

  • A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

Broader concept

Entry terms

  • SOCS3 Protein
  • Suppressor of Cytokine Signaling Protein 3

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-K12545QB-Z

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 4/15/16