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Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Progranulins
Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Progranulins
... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones > Progranulins
Biological Factors > Intercellular Signaling Peptides and Proteins > Progranulins
Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Progranulins
Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Progranulins

Preferred term

Progranulins  

Type

  • mesh:Descriptor

Definition

  • Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.

Broader concept

Narrower concepts

Entry terms

  • 134710-81-9
  • Acrogranin
  • Granulin Precursor
  • Granulin Precursor Protein
  • PC Cell-Derived Growth Factor
  • Proepithelin
  • Progranulin

Allowable Qualifier(s)

In other languages

  • Progranulines

    French

  • 134710-81-9
  • Facteur de croissance dérivé des cellules PC
  • Précurseur de granuline
  • Proépithéline
  • Progranuline
  • Protéine précurseur de granuline

URI

http://data.loterre.fr/ark:/67375/JVR-K2JJG6MG-4

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RDF/XML TURTLE JSON-LD Created 7/9/18, last modified 7/5/19