Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

Biological Factors > Toxins, Biological > Enterotoxins > Cholera Toxin
Biological Factors > Toxins, Biological > Bacterial Toxins > Cholera Toxin
... > Enzymes and Coenzymes > Enzymes > Transferases > Glycosyltransferases > Pentosyltransferases > ADP Ribose Transferases > Cholera Toxin

Preferred term

Cholera Toxin  

Type

  • mesh:Descriptor

Definition

  • An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. The nontoxic, pentameric B protomer of cholera toxin. The cell membrane binding component of cholera toxin. Detoxified aggregate of cholera toxin formed by heat treatment of purified cholera toxin. The catalytic subunit of cholera toxin. It is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE.

Broader concept

Related concepts

Entry terms

  • 9012-63-9
  • Cholera Enterotoxin CT
  • Cholera Exotoxin
  • Choleragen

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Toxine cholérique

    French

  • 9012-63-9
  • Choléragène
  • Entérotoxine cholérique
  • Exotoxine cholérique

URI

http://data.loterre.fr/ark:/67375/JVR-K928J3KP-8

Download this concept:

RDF/XML TURTLE JSON-LD Created 4/22/77, last modified 6/30/21