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Macromolecular Substances > Multiprotein Complexes > Mechanistic Target of Rapamycin Complex 2
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 2
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 2
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > TOR Serine-Threonine Kinases > Mechanistic Target of Rapamycin Complex 2

Preferred term

Mechanistic Target of Rapamycin Complex 2  

Type

  • mesh:Descriptor

Definition

  • A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.

Broader concept

Narrower concepts

Entry terms

  • MTORC-2
  • mTORC2
  • Target of Rapamycin Complex 2
  • TORC2
  • TOR Complex 2

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-KBLJZ16X-2

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 5/21/21