Concept information
Preferred term
Mechlorethamine
Type
-
mesh:Descriptor
Definition
- A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
Broader concept
Entry terms
- 126-85-2 (N-oxide)
- 302-70-5 (N-oxide, HCl)
- 50D9XSG0VR
- 51-75-2
- 55-86-7 (HCl)
- Bis(2-chloroethyl)methylamine
- Chlorethazine
- Chlormethine
- Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
- L0MR697HHI
- Methylchlorethamine
- Mustine
- Nitrogen Mustard
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
126-85-2 (N-oxide)
-
302-70-5 (N-oxide, HCl)
-
50D9XSG0VR
-
51-75-2
-
55-86-7 (HCl)
-
Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
-
L0MR697HHI
URI
http://data.loterre.fr/ark:/67375/JVR-KBLWNJWG-6
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