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Concept information

... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Inorganic Chemicals > Sulfur Compounds > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Organic Chemicals > Sulfur Compounds > Amino Acids, Sulfur > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Neutral > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine
... > Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Essential > Methionine > Methionine Sulfoximine > Buthionine Sulfoximine

Preferred term

Buthionine Sulfoximine  

Type

  • mesh:Descriptor

Definition

  • A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)

Broader concept

Entry terms

  • 5072-26-4
  • Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-KL48511T-5

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RDF/XML TURTLE JSON-LD Created 6/10/96, last modified 6/30/05