Concept information
Preferred term
Transglutaminases
Type
-
mesh:Descriptor
Definition
- Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Broader concept
Narrower concepts
Entry terms
- 80146-85-6 (CAS RN)
- Glutaminyl-Peptide Gamma-Glutamyltransferases
- Protein-glutamine:amine gamma-glutamyltransferase
- Protein-Glutamine gamma-Glutamyltransferases
- Transglutaminase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
80146-85-6 (CAS RN)
-
Glutaminyl-peptide gamma-glutamyltransférases
-
Protein-glutamine:amine gamma-glutamyltransferase
URI
http://data.loterre.fr/ark:/67375/JVR-L34TLTS9-J
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