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... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Mutant Strains > Mice, Inbred mdx
... > Eukaryota > Animals > Animal Population Groups > Animals, Laboratory > Animals, Inbred Strains > Mice, Inbred Strains > Mice, Inbred C57BL > Mice, Inbred mdx
... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Inbred Strains > Mice, Inbred C57BL > Mice, Inbred mdx

Preferred term

Mice, Inbred mdx  

Type

  • mesh:Descriptor

Definition

  • A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.

Broader concept

Related concepts

Entry terms

  • Mice, mdx
  • Mouse, Inbred mdx
  • Mouse, mdx

Allowable Qualifier(s)

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URI

http://data.loterre.fr/ark:/67375/JVR-L9F1WM4N-6

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