Concept information
Preferred term
Dianhydrogalactitol
Type
-
mesh:Descriptor
Definition
- One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Broader concept
Entry terms
- 1,2,5,6-Dianhydrogalactitol
- 1,2-5,6-Dianhydrogalactitol
- 23261-20-3 (Dianhydrogalactitol)
- 4S465RYF7M
- Dianhydrodulcitol
- Diepoxydulcitol
- Diepoxygalactitol
- Galactitol, 1,2:5,6-dianhydro-
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
23261-20-3 (Dianhydrogalactitol)
-
4S465RYF7M
-
Dianhydrogalactitol
-
Galactitol, 1,2:5,6-dianhydro-
URI
http://data.loterre.fr/ark:/67375/JVR-LBVV652P-D
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