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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > Proto-Oncogene Proteins c-bcr
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Proto-Oncogene Proteins c-bcr
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > Rho Guanine Nucleotide Exchange Factors > Proto-Oncogene Proteins c-bcr
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors > Rho Guanine Nucleotide Exchange Factors > Proto-Oncogene Proteins c-bcr

Preferred term

Proto-Oncogene Proteins c-bcr  

Type

  • mesh:Descriptor

Definition

  • A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

Broader concept

Narrower concepts

Entry terms

  • bcr Proto-Oncogene Proteins
  • Breakpoint Cluster Region Protein
  • c-bcr Proteins
  • c-bcr Proto-Oncogene Proteins
  • Proto-Oncogene Protein bcr
  • Proto-Oncogene Protein c-bcr

Allowable Qualifier(s)

In other languages

  • Protéines proto-oncogènes c-bcr

    French

  • Breakpoint cluster region protein
  • Protéine proto-oncogène bcr
  • Protéine proto-oncogène c-bcr
  • Protéines c-bcr
  • Protéines du proto-oncogène bcr
  • Protéines du proto-oncogène c-bcr

URI

http://data.loterre.fr/ark:/67375/JVR-LDDSZL0G-Z

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RDF/XML TURTLE JSON-LD Created 6/30/05, last modified 5/21/21