Concept information
Preferred term
Complement Pathway, Alternative
Type
-
mesh:Descriptor
Definition
- Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Broader concept
Entry terms
- Alternative Complement Activation Pathway
- Alternative Complement Pathway
- Complement Activation Pathway, Alternative
- Properdin Pathway
Allowable Qualifier(s)
In other languages
-
French
-
Voie alterne du complément
-
Voie de la properdine
URI
http://data.loterre.fr/ark:/67375/JVR-LFC9WKNQ-6
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}