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Amino Acids, Peptides, and Proteins > Peptides > Oligopeptides > Angiotensins > Angiotensinogen
... > Amino Acids, Peptides, and Proteins > Proteins > Nerve Tissue Proteins > Neuropeptides > Angiotensins > Angiotensinogen
Amino Acids, Peptides, and Proteins > Peptides > Neuropeptides > Angiotensins > Angiotensinogen
Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones > Angiotensins > Angiotensinogen
... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones > Angiotensins > Angiotensinogen
Biological Factors > Inflammation Mediators > Autacoids > Angiotensins > Angiotensinogen
... > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Protease Inhibitors > Serine Proteinase Inhibitors > Serpins > Angiotensinogen
Amino Acids, Peptides, and Proteins > Peptides > Serpins > Angiotensinogen
Amino Acids, Peptides, and Proteins > Proteins > Serpins > Angiotensinogen
Amino Acids, Peptides, and Proteins > Proteins > Protein Precursors > Angiotensinogen

Preferred term

Angiotensinogen  

Type

  • mesh:Descriptor

Definition

  • An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities.

Broader concept

Entry terms

  • 11002-13-4
  • Angiotensinogen (protein renin substrate)
  • Hypertensinogen
  • Proangiotensin
  • Renin-Substrate
  • Serpin A8
  • SERPINA8

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Angiotensinogène

    French

  • 11002-13-4
  • Angiotensinogen (protein renin substrate)
  • Hypertensiogène
  • Proangiotensine
  • Substrat de la rénine

URI

http://data.loterre.fr/ark:/67375/JVR-LQRH8LFT-0

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RDF/XML TURTLE JSON-LD Created 11/19/74, last modified 6/9/20